Although harsh drugs and strict diet were successfully supressing my devestating MS relapses, disease progression was quickly deteriorating my ability to walk and slowly deteriorating my ability to think. The logical solution for me was to try HSCT, which is not FDA approved, so I left the country to do it. This website documents my research and journey to effect a cure.
Below is a summary of my MS pain/medication experience and management. For those of you who have been following me, you know that pain is my most significant symptom. For the first five years of my MS progression, it was strong and increasing, which is why I was constantly increasing the medication dosage and always looking for something better. You should also know that I have had painful problems with my C-spine, independent of the MS, including a C-spine surgery in year five (and a misdiagnosed L-spine surgery in year two).
As one doctor from Stanford said, anticonvulsants have strong side effects. However, we use a cocktail of two (or more) of them, so we can get the additive benefits with less than additive side effects. Gabapentin (e.g. Neurontin or Gralise) and Pregabalin (Lyrica) are both gabapentinoids, which makes them easy to transition between. Those and Carbamazepine (Tegretol) are all anticonvulsants.
Early MS (1-2 years), increasing pain:
Updated March 31, 2018.
MS stands for Multiple Sclerosis, which basically means "many scars." The scars develop in the central nervous system (CNS), composed of the brain and spinal cord, as the result of an attack from the body's own immune system.
In a normal body, an attack of the CNS would still be a pretty awful thing, but the body would fight the attacking agents, clear away the resulting plaque, then begin to repair the damage. Sclerosis is a type of scar tissue which is atypical of a cleanly healed injury.
In people with MS, the immune system is stuck in fighting mode, commonly thought to be the result of high levels of inflammation in the body. This keeps the CNS stuck in defense mode, preventing normal healing of the damage. The attack is not the result of a typical virus or bacterial infection, it's actually the body's own immune system doing the damage. This process is referred to as "autoimmune" (immune system attacking the self). Dr. Stephen Gundry refers to this process as "friendly fire." There are a hundred or more different autoimmune diseases. Some of the most common ones are Graves' Disease, Hashimoto's Thyroiditis, Lupus, Type 1 Diabetes, Chron's Disease, Rheumatoid Arthritis and Multiple Sclerosis (MS).Add a comment
Analogous Hematopoietic Stem Cell Transplant, sometimes abbreviated as ASCT or HSCT, is a process by which your own (analogous) hematopoietic stem cells (i.e. immune system stem cells), grown in your own bone marrow, are harvested from your body (usually through your blood), then given back to you after chemotherapy (which wipes out your existing immune system) to rebuild a new immune system (without memory of your autoimmune disease) from scratch.
This is in effect a reboot of the immune system.
There are many types of stem cells in the body, each which can grow in to particular types of new cells. Hematopoietic stem cells grow into new immune cells, and they are abundant and easy to capture. Furthermore, a mobilizing drug (i.e. filgrastim) can be used to encourage the bone marrow to generate HSCs by the millions.